DdBIC

Chemical Structure : DdBIC

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货号: PC-26968Not For Human Use, Lab Use Only.

DdBIC is a specific small molecule agonist of orphan nuclear receptor Nur77, binds to ligand binding domain (LBD) with ITC Kd of 714 nM, triggers GSDMC-mediated pyroptosis by regulating heme levels.

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生物&药学活性

DdBIC is a specific small molecule agonist of orphan nuclear receptor Nur77, binds to ligand binding domain (LBD) with ITC Kd of 714 nM, triggers GSDMC-mediated pyroptosis by regulating heme levels.
DdBIC activates the PERK-mediated ISR pathway to induce pyroptosis.
DdBIC promotes the accumulation of granzyme B (GZMB) in the cytosol.
DdBIC induces Nur77 translocation to the mitochondria to activate the hemoprotein SDHA to overconsume succinyl-CoA, subsequently disrupting the homeostasis of heme in the SDH complex and resulting in electron leakage to induce mito-ROS production.
DdBIC induces downstream OPA1 cleavage and subsequent released into the cytoplasm.
Cytosolic OPA1 activated PERK to induce the integrated stress response (ISR), which further activated granzyme B to cleave GSDMC, culminating in the induction of pyroptosis.

物理化学性质&存储条件

分子量	330.47
分子式	C20H30N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	dodecyl 1H-benzo[d]imidazole-6-carboxylate

参考文献

1. Liu-Zheng Wu, et al. Signal Transduct Target Ther. 2025 Dec 17;10(1):413.

DdBIC

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DdBIC

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