Darlifarnib (KO-2806) | FTase inhibitor | Probechem Biochemicals

Chemical Structure : Darlifarnib

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Darlifarnib (KO-2806, KO2806)

货号: PC-24121Not For Human Use, Lab Use Only.

Darlifarnib (KO-2806, KO2806) is a potent, specific farnesyltransferase (FTase) inhibitor with IC50 of 2.4 nM, while sparing activity of GGTase (IC50>1 uM).

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生物&药学活性

Darlifarnib (KO-2806, KO2806) is a potent, specific farnesyltransferase (FTase) inhibitor with IC50 of 2.4 nM, while sparing activity of GGTase (IC50>1 uM).

KO-2806 enhances adagrasib's inhibition of mTORC1 signaling by blocking RHEB farnesylation.

KO-2806 deepens responses of NSCLC models to KRASG12C inhibition and inhibits mTORC1 in vivo.

KO-2806 blocks rebound of mTOR signaling and deepens antitumor responses to mutant-selective and pan-RAS inhibitors in colorectal cancer.

KO-2806 resensitizes refractory or relapsing NSCLC tumors to mutant-selective or pan-RAS inhibition.

物理化学性质&存储条件

分子量	468.52
分子式	C29H20N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-3-amino-3-(1-methyl-1H-imidazol-5-yl)-6-oxa-2(4,6)-quinolina-1,4(1,3)-dibenzenacyclohexaphane-22,44-dicarbonitrile

参考文献

1. Patent WO2024137751 A1.

2. Patent WO2024233539 A1.

Darlifarnib (KO-2806, KO2806)

生物&药学活性

物理化学性质&存储条件

参考文献

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Darlifarnib (KO-2806, KO2806)

生物&药学活性

物理化学性质&存储条件

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