Dacinostat (LAQ824) | HDAC inhibitor | Probechem Biochemicals

Chemical Structure : Dacinostat

CAS No.: 404951-53-7

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Dacinostat (LAQ824, NVP-LAQ824)

货号: PC-49004Not For Human Use, Lab Use Only.

Dacinostat (NVP-LAQ824) is a potent histone deacetylase (HDAC) inhibitor with IC50 of 32 nM, transcriptionally activates the p21 promoter in reporter gene assays with AC50 of 0.3 uM.

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5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3280	In stock
50 mg	￥5280	In stock
100 mg		Get quote

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生物&药学活性

Dacinostat (NVP-LAQ824) is a potent histone deacetylase (HDAC) inhibitor with IC50 of 32 nM, transcriptionally activates the p21 promoter in reporter gene assays with AC50 of 0.3 uM.
LAQ824 (30 nM) resulted in a delayed (2 h) increase in reactive oxygen species (ROS), induction of p21(WAF1/CIP1), pRb dephosphorylation, growth arrest of cells in G(0)/G(1) phase, and differentiation in in human leukemia cells (U937 and Jurkat).
NVP-LAQ824 selectively inhibited growth of cancer cell lines at submicromolar levels after 48-72 h of exposure.
NVP-LAQ824 increased histone H3 and H4 acetylation level in cancer cell lines.
NVP-LAQ824 exhibited antitumor effects in a xenograft animal model.

物理化学性质&存储条件

分子量	379.5
分子式	C22H25N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2E)-N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide

参考文献

1. Jin JX, et al. Cell Physiol Biochem. 2017;41(3):1255-1266.

2. Roberto R Rosato, et al. Mol Pharmacol. 2006 Jan;69(1):216-25.

3. Atadja P, et al. Cancer Res. 2004 Jan 15;64(2):689-95.

Dacinostat (LAQ824, NVP-LAQ824)

生物&药学活性

物理化学性质&存储条件

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Dacinostat (LAQ824, NVP-LAQ824)

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物理化学性质&存储条件

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