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首页-抗体和重组蛋白-Biosimilar Antibody-Dacetuzumab
Dacetuzumab

Chemical Structure : Dacetuzumab

CAS No.: 880486-59-9

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Dacetuzumab (Anti-human CD40 mAb, human IgG1-Kappa; SGN-40)

货号: PC-Ab1099Not For Human Use, Lab Use Only.

Dacetuzumab (SGN-40, huS2C6) is a humanized anti-CD40 monoclonal antibody that specifically binds to and works against a molecule called a CD40 receptor. Dacetuzumab has been used in trials studying the treatment of Multiple Myeloma, Non-Hodgkin Lymphoma, Leukemia, Lymphocytic, Chronic, and Lymphoma, Large B-Cell, Diffuse. It is a humanized anti-CD40 antibody and induces cytotoxicity in human multiple myeloma cells. Dacetuzumab demonstrated antitumor activity in relapsed/refractory diffuse large

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1 mg ￥3580 In stock
5 mg ￥7580 In stock
10 mg ￥12800 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Dacetuzumab (SGN-40, huS2C6) is a humanized anti-CD40 monoclonal antibody that specifically binds to and works against a molecule called a CD40 receptor. Dacetuzumab has been used in trials studying the treatment of Multiple Myeloma, Non-Hodgkin Lymphoma, Leukemia, Lymphocytic, Chronic, and Lymphoma, Large B-Cell, Diffuse. It is a humanized anti-CD40 antibody and induces cytotoxicity in human multiple myeloma cells. Dacetuzumab demonstrated antitumor activity in relapsed/refractory diffuse large B-cell lymphoma (DLBCL). Dacetuzumab induces ADCC and ADCP via interaction with Fc receptors on T cells, NK cells, monocytes, and macrophages.

物理化学性质&存储条件

分子量
分子式 Human IgG1-Kappa
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

PBS, pH 7.0 Contains no stabilizers or preservatives
Chemical Name/SMILES

Dacetuzumab; SGN-40; SGN40; huS2C6; SEA-40; 880486-59-9; Cluster of Differentiation 40; CD40/TNFR5; Anti-human CD40

参考文献

1. 1, Lewis TS, et al. Clin Cancer Res. 2011 Jul 15;17(14):4672-81.  2, Lewis TS, et al. Leukemia. 2011 Jun;25(6):1007-16. 3, Huang EP, et al. BMC Cancer. 2010 Oct 27;10:586.  4, Burington B, et al. Sci Transl Med. 2011 Mar 16;3(74):74ra22.

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