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首页-小分子抑制剂&激动剂-GPCR-Adrenergic Receptor-Dabuzalgron
Dabuzalgron

Chemical Structure : Dabuzalgron

CAS No.: 219311-44-1

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Dabuzalgron (Ro 115-1240, RO115-1240)

货号: PC-24569Not For Human Use, Lab Use Only.

Dabuzalgron (Ro 115-1240) is an orally active and selective α-1A adrenergic receptor agonist with pKi of 7.39 for the displacement of [3H]-prazosin binding to CHO-K1 membranes.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Dabuzalgron (Ro 115-1240) is an orally active and selective α-1A adrenergic receptor agonist with pKi of 7.39 for the displacement of [3H]-prazosin binding to CHO-K1 membranes.
Dabuzalgron shows greater affinity for alpha1A than for alpha1B and alpha1D subtypes (>3o-fold).
Dabuzalgron produced non-selective, dose-dependent increases in intraurethral and arterial blood pressures in anaesthetized micropigs and rabbits.

物理化学性质&存储条件

分子量 317.79
分子式 C12H16ClN3O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(6-Chloro-3-((4,5-dihydro-1H-imidazol-2-yl)methoxy)-2-methylphenyl)methanesulfonamide

参考文献

1. Blue DR, et al. BJU Int. 2004 Jan;93(1):162-70.

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