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首页-抗体药物偶连体和PROTACs-PROTAC-DZ-865B
DZ-865B

Chemical Structure : DZ-865B

CAS No.: 3105664-87-4

DZ-865B (DZ865B)

货号: PC-26284Not For Human Use, Lab Use Only.

DZ-865B is a selective BCL6 degrader with DC50 of 2.7 uM and 4.7 uM in DLBCL cell lines OCI-LY-1 and SU-DHL-4 respectively, effectively suppresses DLBCL cell growth.

规格 价格 库存 数量
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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

DZ-865B is a selective BCL6 degrader with DC50 of 2.7 uM and 4.7 uM in DLBCL cell lines OCI-LY-1 and SU-DHL-4 respectively, effectively suppresses DLBCL cell growth.

物理化学性质&存储条件

分子量 865.94
分子式 C43H44FN9O8S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5-(cyclopent-1-en-1-yl)-N-(4-((2-(4-(3-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)ethoxy)propanoyl)piperazin-1-yl)-5-fluoropyrimidin-4-yl)amino)-2-methoxyphenyl)thiophene-2-carboxamide

参考文献

1. Yanfeng Wang, et al. Oncol Res. 2026 Feb 24;34(3):23.

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