DZ-837 | BCL6 degrader | Probechem Biochemicals

Chemical Structure : DZ-837

加入收藏

DZ-837 (DZ837)

货号: PC-28734Not For Human Use, Lab Use Only.

DZ-837 is an effective BCL6-targeting PROTAC degrader with DC50 values around 600 nM in SU-DHL-4 and DOHH2 cells, effectively inhibits cell growth in BCL6-dependent DLBCL cell lines, exhibits synergistic antiproliferative response and overcame acquired resistance against DLBCL cells combined with Ibrutinib.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

DZ-837 is an effective BCL6-targeting PROTAC degrader with DC50 values around 600 nM in SU-DHL-4 and DOHH2 cells, effectively inhibits cell growth in BCL6-dependent DLBCL cell lines, exhibits synergistic antiproliferative response and overcame acquired resistance against DLBCL cells combined with Ibrutinib.

物理化学性质&存储条件

分子量	837.92
分子式	C42H44FN9O7S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(1-cyclopentenyl)-N-(4-((2-(4-(2-(2-((2-(2,6-dioxo-3-piperidinyl)-1,3-dioxo-4-isoindolinyl)amino)ethoxy)ethyl)-1-piperazinyl)-5-fluoro-4-pyrimidinyl)amino)-2-methoxyphenyl)thiophene-2-carboxamide

参考文献

1. Dazhao Mi, et al. Eur J Med Chem. 2024 Nov 5:277:116789.

DZ-837 (DZ837)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

DZ-837 (DZ837)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.