DYRK inhibitor FC-2

Chemical Structure : DYRK inhibitor FC-2

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货号: PC-27002Not For Human Use, Lab Use Only.

DYRK inhibitor FC-2 is a potent, selective, reversible, ATP-competitive inhibitor of Dual-specificity tyrosine-regulated kinases (DYRKs) with IC50 of 19 nM (DYRK1A).

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

DYRK inhibitor FC-2 is a potent, selective, reversible, ATP-competitive inhibitor of Dual-specificity tyrosine-regulated kinases (DYRKs) with IC50 of 19 nM (DYRK1A).
The gatekeeper mutants F238L and M240R demonstrated resistance to FC-2 with IC50 of 400-450 nM, F238L-M240R double mutant has IC50 of 5 uM.
FC-2 (5-20 uM) reduces neurosphere proliferation and cell invasion of GBM cell line U87MG by specifically targeting DYRK1A.
FC-2 enhances EGFR ubiquitination, leading to its lysosomal degradation in EGFR-dependent glioblastoma cell-based models.
FC-2 (2 mg/kg daily) attenuates DYRK1A-mediated tumorigenesis in U87MG subcutaneous xenograft model of Nu/J nude mice.

物理化学性质&存储条件

分子量	287.29
分子式	C14H9NO4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-([1,3]dioxolo[4',5':4,5]benzo[1,2-d]thiazol-6-yl)benzene-1,2-diol

参考文献

1. Venkataramani P, et al. Cell Chem Biol. 2026 Jun 10:S2451-9456(26)00157-1.