DW09849

Chemical Structure : DW09849

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货号: PC-25286Not For Human Use, Lab Use Only.

DW09849 is a highly potent, selective PI3Kα inhibitor, inhibits proliferation of rhabdomyosarcoma RH30 cells.

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生物&药学活性

DW09849 is a highly potent, selective PI3Kα inhibitor, inhibits proliferation of rhabdomyosarcoma RH30 cells.
DW09849 significantly and persistently blocks PI3K/protein kinase B signaling in RH30 cells, which consequently arrested RH30 cells in the G1 phase.
DW09849 selectively suppresses the proliferation and clonogenesis of transformed RK3E/HR cells harboring oncogenic mutation of p110α H1047R, as well as a panel of human breast cancer cells containing mutated PI3Kα.
DW09849 demonstrates preference against H1047R mutated PI3Kα in molecular docking stimulation.
DW09849 selectively targeting PI3Kα with less off-target effects than PIK-75.

物理化学性质&存储条件

分子量	430.26
分子式	C18H16BrN5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-N'-((6-bromoimidazo[1,2-a]pyridin-3-yl)methylene)-N-ethyl-2-methyl-5-nitrobenzohydrazide

参考文献

1. Liu JL, et al. J Pharmacol Exp Ther. 2014 Mar;348(3):432-41.

DW09849

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物理化学性质&存储条件

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DW09849

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物理化学性质&存储条件

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