DSP-1053 | SERT inhibitor, 5-HT1A agonist | Probechem Biochemicals

Chemical Structure : DSP-1053

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DSP-1053 (DSP1053)

货号: PC-63256Not For Human Use, Lab Use Only.

DSP-1053 is a novel potent serotonin reuptake (SERT) inhibitor with 5-HT1A partial agonistic activity that binds to human serotonin transporter and 5-HT1A receptor with Ki of 1.02 and 5.05 nM, respectively.

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生物&药学活性

DSP-1053 is a novel potent serotonin reuptake (SERT) inhibitor with 5-HT1A partial agonistic activity that binds to human serotonin transporter and 5-HT1A receptor with Ki of 1.02 and 5.05 nM, respectively.
DSP-1053 inhibits serotonin transporter with IC50 of 2.74 nM and shows an intrinsic activity for 5-HT1A receptors of 70.0%.
DSP-1053 dose-dependently increases extracellular 5-HT levels in rat microdialysis at 3-10 mg/kg, demonstrates antidepressant-like effect in vivo.

物理化学性质&存储条件

分子量	660.62
分子式	C32H38BrNO7S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(2-{4-[4-Bromo-3-(2-methoxyethoxy)benzyl]piperidin-1-yl}ethyl)-2,3-dihydro-4H-chromen-4-one benzenesulfonate

参考文献

1. Yoshinaga H, et al. Bioorg Med Chem. 2018 May 1;26(8):1614-1627.

2. Kato T, et al. Pharmacol Res Perspect. 2015 Jun;3(3):e00142.

DSP-1053 (DSP1053)

生物&药学活性

物理化学性质&存储条件

参考文献

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DSP-1053 (DSP1053)

生物&药学活性

物理化学性质&存储条件

参考文献

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