DS2969b | GyrB inhibitor | Probechem Biochemicals

Chemical Structure : DS2969b

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DS2969b (DS11960558)

货号: PC-62606Not For Human Use, Lab Use Only.

DS2969b (DS11960558) is a novel orally active GyrB inhibitor, inhibits the supercoiling activity of C. difficile DNA gyrase with IC50 of 20 ng/mL.

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100 mg		Get quote

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生物&药学活性

DS2969b (DS11960558) is a novel orally active GyrB inhibitor, inhibits the supercoiling activity of C. difficile DNA gyrase with IC50 of 20 ng/mL.
DS2969b (DS11960558) showes potent in vitro activity against C. difficile clinical isolates with MIC90 of 0.06 μg/mL, 2-, 32-, and 16-fold lower than the MIC90 of fidaxomicin, vancomycin, and metronidazole, respectively.
DS2969b (DS11960558) demonstrates excellent in vivo activity against Clostridium difficile (CDI) model.

物理化学性质&存储条件

分子量	428.936
分子式	C17H25ClN6O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-chloro-5-ethyl-N-{(3S,4R)-1-[5-(2-hydroxypropan-2-yl)-1,3,4-thiadiazol-2-yl]-3-methoxypiperidin-4-yl}-1H-imidazole-2-carboxamide

参考文献

1. Mathur T, et al. Antimicrob Agents Chemother. 2018 Feb 12. pii: AAC.02157-17.

2. Vandell AG, et al. Antimicrob Agents Chemother. 2018 Feb 12. pii: AAC.02537-17.

DS2969b (DS11960558)

生物&药学活性

物理化学性质&存储条件

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DS2969b (DS11960558)

生物&药学活性

物理化学性质&存储条件

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