DS-3032b |Cas:1398568-47-2 Buy DS-3032b from ProbeChem, Global Biochemicals Supplier

Chemical Structure : DS-3032

CAS No.: 1398568-47-2

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DS-3032 (DS 3032; DS3032; Milademetan)

货号: PC-60302Not For Human Use, Lab Use Only.

Milademetan (DS-3032) is a potent, selective, orally available MDM2-p53 inhibitor with potential antineoplastic activity.

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2 mg	￥2580	In stock
5 mg	￥4580	In stock
10 mg	￥7580	In stock
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生物&药学活性

Milademetan (DS-3032) is a potent, selective, orally available MDM2-p53 inhibitor with potential antineoplastic activity.
Milademetan (DS-3032) binds to, and prevents the binding of MDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53.
Milademetan (DS-3032) restores p53 signaling and leads to the p53-mediated induction of tumor cell apoptosis.

物理化学性质&存储条件

分子量	618.531
分子式	C30H34Cl2FN5O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3'R,4'S,5'R)-N-((3S,6R)-6-carbamoyltetrahydro-2H-pyran-3-yl)-6''-chloro-4'-(2-chloro-3-fluoropyridin-4-yl)-4,4-dimethyl-2''-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3''-indoline]-5'-carboxamide

参考文献

1. Ishizawa J, et al. Cancer Res. 2018 May 15;78(10):2721-2731.

DS-3032 (DS 3032; DS3032; Milademetan)

生物&药学活性

物理化学性质&存储条件

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DS-3032 (DS 3032; DS3032; Milademetan)

生物&药学活性

物理化学性质&存储条件

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