DS-1039 | GPR39 agonist | Probechem Biochemicals

Chemical Structure : DS-1039

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DS-1039 (DS1039)

货号: PC-25715Not For Human Use, Lab Use Only.

DS-1039 is a potent, selective GPR39 agonist, demonstrates excellent induction of intracellular Ca2+ concentration with EC50 of 0.01 uM.

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生物&药学活性

DS-1039 is a potent, selective GPR39 agonist, demonstrates excellent induction of intracellular Ca2+ concentration with EC50 of 0.01 uM.
DS-1039 shows no significant response with 168 other GPCRs and 87 molecular targets.
DS-1039 exhibitsexcellent induction of chloride secretion (EC50 = 0.051 μM) in hBE cells.
DS-1039 induces chloride channel opening in short circuit currents in 3D-cultured primary human bronchial epithelial cells.
DS-1039 induces calcium mobilization (EC50 = 1.0 μM) and chloride secretion (EC50 = 0.18 μM) in mouse bronchial epithelial cells, induces hyperpolarization in mouse NPD.

物理化学性质&存储条件

分子量	292.72
分子式	C14H13ClN2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(2-chlorobenzyl)-4-methoxy-6-methylpyrimidine-2-carboxylic acid

参考文献

1. Muneoka S, et al. Eur J Pharmacol. 2025 Nov 15;1007:178257.

DS-1039 (DS1039)

生物&药学活性

物理化学性质&存储条件

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DS-1039 (DS1039)

生物&药学活性

物理化学性质&存储条件

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