DRAK2 inhibitor I14

Chemical Structure : DRAK2 inhibitor I14

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货号: PC-26973Not For Human Use, Lab Use Only.

DRAK2 inhibitor I14 is a potent and selective, orally efficacious DRAK2 (STK17B) inhibitor with IC50 of 198.5 nM.

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50 mg		Get quote
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250 mg		Get quote

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生物&药学活性

DRAK2 inhibitor I14 is a potent and selective, orally efficacious DRAK2 (STK17B) inhibitor with IC50 of 198.5 nM.
DRAK2 inhibitor I14 enhanced glucose-stimulated insulin secretion (GSIS) in mouse pancreatic islets by 1.86-fold (low dose) and 1.72-fold (high dose).
DRAK2 inhibitor I14 elevated mitochondrial membrane potential (MMP) in INS-1E cells by 1.08-fold and 1.10-fold, respectively.
DRAK2 inhibitor I14 mitigated palmitic acid (PA)-induced MMP impairment and apoptosis.
DRAK2 inhibitor I14 significantly improved glucose tolerance in an oral glucose tolerance test (OGTT) in vivo.

物理化学性质&存储条件

分子量	402.47
分子式	C22H18N4O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(3-(3-benzylureido)thieno[2,3-b]pyridin-5-yl)benzamide

参考文献

1. Shu Y, et al. Eur J Med Chem. 2026 Jun 3;316:119033.