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首页-小分子抑制剂&激动剂-GPCR-Adenosine Receptor-DPTN dihydrochloride
DPTN dihydrochloride

Chemical Structure : DPTN dihydrochloride

CAS No.: 325767-87-1

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DPTN dihydrochloride (MRS7799)

货号: PC-28427Not For Human Use, Lab Use Only.

DPTN dihydrochloride (MRS7799) is a potent and selective A3 adenosine receptor (A3AR) antagonist with of 1.65, 9.61, and 8.53 nM for human, mouse, and rat A3AR respectively, and EC50 of 63.8 nM in A3AR-βarr2 recruitment assay.

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10 mg ￥1480 In stock
25 mg ￥2580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

DPTN dihydrochloride (MRS7799) is a potent and selective A3 adenosine receptor (A3AR) antagonist with of 1.65, 9.61, and 8.53 nM for human, mouse, and rat A3AR respectively, and EC50 of 63.8 nM in A3AR-βarr2 recruitment assay.

物理化学性质&存储条件

分子量 459.39
分子式 C22H20Cl2N4OS
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(4-(3,5-Dimethylphenyl)-5-(pyridin-4-yl)thiazol-2-yl)nicotinamide dihydrochloride

参考文献

1. Zhan-Guo Gao, et al. Purinergic Signal. 2021 Dec;17(4):737-746.

2. Suresh RR, et al. ACS Med Chem Lett. 2022 Mar 2;13(4):623-631.

3. Pottie E, et al. ACS Pharmacol Transl Sci. 2023 Aug 9;6(9):1266-1274.

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