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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Parasite-DNDI-8219
DNDI-8219

Chemical Structure : DNDI-8219

CAS No.: 2222660-40-2

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DNDI-8219 (DNDI8219)

货号: PC-63237Not For Human Use, Lab Use Only.

DNDI-8219 is a novel potent, orally active antileishmanial agent with IC50 of 0.19 uM against Leishmania donovani (L. don).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    DNDI-8219 is a novel potent, orally active antileishmanial agent with IC50 of 0.19 uM against Leishmania donovani (L. don).
    DNDI-8219 also has IC050 of 0.53 and 0.15 uM against L. inf and T. cruzi.
    DNDI-8219 displayes promising activity in the more stringent Leishmania infantum hamster model, with better solubility and pharmacokinetic properties, as well as minimal hERG inhibition.

    物理化学性质&存储条件

    分子量 345.234
    分子式 C13H10F3N3O5
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-2-nitro-6-(4-(trifluoromethoxy)phenoxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine

    参考文献

    1. Thompson AM, et al. J Med Chem. 2018 Mar 22;61(6):2329-2352.

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