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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Parasite-DNDI-6148
DNDI-6148

Chemical Structure : DNDI-6148

CAS No.: 2243909-59-1

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DNDI-6148 (DNDI6148)

货号: PC-26662Not For Human Use, Lab Use Only.

DNDI-6148 is a potent, selective inhibitor of Visceral leishmaniasis (VL) with EC50 of 1.8 uM and 1.4 uM for intramacrophage L. infantum and L. donovani, inhibits Leishmania cleavage and polyadenylation specificity factor (CPSF3) endonuclease.

规格 价格 库存 数量
2 mg ￥2580 In stock
5 mg ￥4280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

DNDI-6148 is a potent, selective inhibitor of Visceral leishmaniasis (VL) with EC50 of 1.8 uM and 1.4 uM for intramacrophage L. infantum and L. donovani, inhibits Leishmania cleavage and polyadenylation specificity factor (CPSF3) endonuclease.

物理化学性质&存储条件

分子量 335.13
分子式 C16H14BN5O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
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Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(1-Hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)-5-methyl-1-(pyridin-2-yl)-1H-1,2,3-triazole-4-carboxamide

参考文献

1. Mowbray CE, et al. J Med Chem. 2021 Nov 11;64(21):16159-16176.

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