DNA polymerase theta inhibitor | POLθ inhibitor | Probechem Biochemicals

Chemical Structure : DNA polymerase theta inhibitor

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DNA polymerase theta inhibitor (POLθi)

货号: PC-20598Not For Human Use, Lab Use Only.

DNA polymerase theta inhibitor (POLθi) is a small-molecule DNA polymerase theta (POLθ) inhibitor, binds to an allosteric pocket in the thumb subdomain of POLθ, inhibits its polymerase activity.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

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生物&药学活性

DNA polymerase theta inhibitor (POLθi) is a small-molecule DNA polymerase theta (POLθ) inhibitor, binds to an allosteric pocket in the thumb subdomain of POLθ, inhibits its polymerase activity.

物理化学性质&存储条件

分子量	433.51
分子式	C24H27N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(NC1=CC=C(C)N=C1)NC2=NC(C3=CC=C(OCC4(C)COCC4)C(C)=C3)=CN=C2

参考文献

1. Anna Schrempf, et al. Cell Rep. 2022 Nov 29;41(9):111716.