DN203316 | PPARδ agonist | Probechem Biochemicals

Chemical Structure : DN203316

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DN203316 (DN-203316)

货号: PC-26999Not For Human Use, Lab Use Only.

DN203316 is a potent, selective peroxisome proliferator-activated receptor delta (PPARδ) agonist with EC50 of 0.02 uM (hPPARδ).

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生物&药学活性

DN203316 is a potent, selective peroxisome proliferator-activated receptor delta (PPARδ) agonist with EC50 of 0.02 uM (hPPARδ).
DN203316 attenuates cholesterol-induced ferroptosis in hepatocytes, without detectable toxicity.
DN203316 restores expression of xCT and GPX4 at both the transcript and protein levels and increases GSH levels in cholesterol-exposed hepatocytes.
DN203316 reduces exosomal dsDNA release from ferroptotic hepatocytes and inhibits STING-driven fibrogenesis in MASH.
DN203316 (3 mg/kg/day, i.p.) alleviates MASH by suppressing ferroptosis and STING-driven fibrogenesis in HFHC-induced MASH mice.

物理化学性质&存储条件

分子量	440.46
分子式	C19H15F3N2O3S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2-methyl-4-(((5-(4-(trifluoromethyl)phenyl)-1,3,4-thiadiazol-2-yl)methyl)thio)phenoxy)acetic acid

参考文献

1. Kim YJ, et al. Exp Mol Med. 2026 Jun 5. doi: 10.1038/s12276-026-01740-0.

DN203316 (DN-203316)

生物&药学活性

物理化学性质&存储条件

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DN203316 (DN-203316)

生物&药学活性

物理化学性质&存储条件

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