DN1679 | CDK12/13 degrader | Probechem Biochemicals

Chemical Structure : DN1679

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DN1679 (DN-1679)

货号: PC-28730Not For Human Use, Lab Use Only.

DN1679 is a potent, orally bioavailable, and highly selective CDK12/13 dual degrader with DC50 of 8.8/9.8 nM, suppresses TNBC growth both in vitro and in vivo.

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生物&药学活性

DN1679 is a potent, orally bioavailable, and highly selective CDK12/13 dual degrader with DC50 of 8.8/9.8 nM, suppresses TNBC growth both in vitro and in vivo.
DN1679 exhibits undesired activity against CDK4, CDK6, and CDK9.
DN1679 significantly inhibited the proliferation of multiple TNBC cell lines, with IC50 values of 31.7 ± 1.1 nM in MDA-MB-157, 49.1 ± 2.5 nM in MDA-MB-231, and 121.4 ± 1.4 nM in MDA-MB-468 cells.
DN1679 effectively suppressed the mRNA levels of key DDR genes, including ATM, ATR, BRCA1, FANCD2, FANCI, and RAD51 in a time-dependent manner.
DN1679 demonstrates robust synergy with the PARP inhibitor olaparib in vivo, leading to significantly enhanced antitumor efficacy.

物理化学性质&存储条件

分子量	1068.12
分子式	C52H53F4N11O8S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-(2-(((3R)-1-((1-(2-(2,6-Dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)methyl)pyrrolidin-3-yl)oxy)pyrimidin-5-yl)phenyl)-N-((1r,4R)-4-((4-(5-(methylsulfonyl)pyridin-3-yl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)cyclohexyl)acetamide

参考文献

1. Danni Chen, et al. J Med Chem. 2026 Jan 22;69(2):1033-1048.

DN1679 (DN-1679)

生物&药学活性

物理化学性质&存储条件

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DN1679 (DN-1679)

生物&药学活性

物理化学性质&存储条件

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