DMT207 | DNMT1 inhibitor | Probechem Biochemicals

Chemical Structure : DMT207

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DMT207 (DMT-207)

货号: PC-26176Not For Human Use, Lab Use Only.

DMT207 is a potent, selective, non-nucleoside DNMT1 (DNA Methyltransferase 1) inhibitor with IC50 of 6.88 nM.

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生物&药学活性

DMT207 is a potent, selective, non-nucleoside DNMT1 (DNA Methyltransferase 1) inhibitor with IC50 of 6.88 nM.
DMT207 (50-500 nM) elevates γ-globin in adult primary erythroblasts.
DMT207 specifically induced the expression of γ-globin in both mRNA and protein levels, and maintained higher cell viability in primary erythroblasts from β-Thalassemia patients.
DMT207 induces εy- and βh1-globin in β-thalassemia mice.
DMT207 mediates DNMT1 degradation by enhancing its interaction with UHRF1.

物理化学性质&存储条件

分子量	533.65
分子式	C27H31N7O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-2-(6-((2-amino-1-(4-methoxyphenyl)-2-oxoethyl)thio)-3,5-dicyano-4-ethyl-1H-pyrrolo[2,3-b]pyridin-1-yl)-N-(2-(dimethylamino)ethyl)-N-methylacetamide

参考文献

1. Yijie Shen, et al. Adv Sci (Weinh). 2026 Feb;13(11):e13469.

DMT207 (DMT-207)

生物&药学活性

物理化学性质&存储条件

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DMT207 (DMT-207)

生物&药学活性

物理化学性质&存储条件

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