DL0410 | AChE/BuChE inhibitor, H3R antagonist | Probechem Biochemicals

Chemical Structure : DL0410

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DL0410 (DL-0410)

货号: PC-26290Not For Human Use, Lab Use Only.

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生物&药学活性

DL0410 is a synthetic dual acetylcholinesterase (AChE)/butyrocholinesterase (BuChE) inhibitor with IC50 of 0.286/3.96 uM, also inhibit histamine receptor 3 (H3R) with IC50 of 0.308 uM, shows neuroprotective effects both in vitro and in vivo.
DL0410 showed better protection against Aβ-induced neurotoxicity than donepezil and rivastigmine, improved cell viability of APPsw-SY5Y cells subjected to copper.
DL0410 (1-9 mg/kg) shows beneficial effects on learning and memory capabilities in an Aβ1–42-induced amnesia mouse model.
DL0410 (9 mg/kg) significantly decreased β-APP protein levels in the cerebral cortices of Aβ1-42-treated mice.
DL0410 protects APPsw-SY5Y cells by reversing copper-induced Δψm loss.
DL0410 attenuated cell apoptosis through the regulation of the Akt/JNK pathway.

物理化学性质&存储条件

分子量	505.52
分子式	C28H38Cl2N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1,1'-([1,1'-biphenyl]-4,4'-diyl)bis(3-(piperidin-1-yl)propan-1-one) dihydrochloride

参考文献

1. Zhou D, et al. Acta Pharmacol Sin. 2016 Nov;37(11):1401-1412.

2. Yang RY, et al. Pharmacol Biochem Behav. 2015 Dec;139(Pt A):15-26.

DL0410 (DL-0410)

生物&药学活性

物理化学性质&存储条件

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DL0410 (DL-0410)

生物&药学活性

物理化学性质&存储条件

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