DK-I-56-1

Chemical Structure : DK-I-56-1

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货号: PC-25017Not For Human Use, Lab Use Only.

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生物&药学活性

DK-I-56-1 is a selective positive allosteric modulator (PAM) of α6 GABAA receptors, enhances GABA-induced chloride flux at α6β3γ2, α6β3δ, or α6β3 receptors at sub-µM or low µM concentrations.
DK-I-56-1 is the deuterated version of PZ-II-029.
DK-I-56-1 does not or only weakly modulates GABA-induced currents at αxβ3γ2 GABAA receptors containing α1, α2, α3, α4, or α5 subunits below 1 µM concentration.
DK-I-56-1 inhibited the development and reduced the established trigeminal neuropathic pain in a rat model of chronic constriction injury of the infraorbital branch of the trigeminal nerve.

物理化学性质&存储条件

分子量	324.35
分子式	C18H12D3N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-methoxy-2-(4-(methoxy-d3)phenyl)-2,5-dihydro-3H-pyrazolo[4,3-c]quinolin-3-one

参考文献

1. Vasović D, et al. Eur J Pain. 2019 May;23(5):973-984.

DK-I-56-1

生物&药学活性

物理化学性质&存储条件

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DK-I-56-1

生物&药学活性

物理化学性质&存储条件

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