DJ101 | Tubulin inhibitor | Probechem Biochemicals

Chemical Structure : DJ101

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DJ101 (DJ-101, DJ 101)

货号: PC-60807Not For Human Use, Lab Use Only.

A novel potent and metabolically stable tubulin inhibitor that can circumvent the drug efflux pumps responsible for multidrug resistance of existing tubulin inhibitors.

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生物&药学活性

DJ101 is a potent and metabolically stable tubulin inhibitor that can circumvent the drug efflux pumps responsible for multidrug resistance of existing tubulin inhibitors.
DJ101 demonstrates cytotoxicty in a panel of human metastatic melanoma cell lines harboring major clinically relevant mutations with IC50 of 7-10 nM.
DJ101 disrupts microtubule networks, suppresses anchorage-dependent melanoma colony formation, and impaires cancer cell migration.
DJ101 inhibits tumor growth and reduced lung metastasis in melanoma-bearing mice, also completely inhibits tumor growth in a paclitaxel-resistant xenograft mouse model.

物理化学性质&存储条件

分子量	400.438
分子式	C23H20N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(1H-indol-4-yl)-4-(3,4,5-trimethoxyphenyl)-1H-imidazo[4,5-c]pyridine

参考文献

1. Arnst KE, et al. Cancer Res. 2018 Jan 1;78(1):265-277.

DJ101 (DJ-101, DJ 101)

生物&药学活性

物理化学性质&存储条件

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DJ101 (DJ-101, DJ 101)

生物&药学活性

物理化学性质&存储条件

参考文献

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