DIX-01 | IKZF1/3 and GSPT1 degrader | Probechem Biochemicals

Chemical Structure : DIX-01

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DIX-01 (DIX01)

货号: PC-28662Not For Human Use, Lab Use Only.

DIX-01 is a potent dual IKZF1/3 and GSPT1 molecular glue degrader with DC50 values of 19.80 nM for IKZF1, 45.31 nM for IKZF3, and 120.1 nM for GSPT1 in MV4-11 cells.

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100 mg		Get quote

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生物&药学活性

DIX-01 is a potent dual IKZF1/3 and GSPT1 molecular glue degrader with DC50 values of 19.80 nM for IKZF1, 45.31 nM for IKZF3, and 120.1 nM for GSPT1 in MV4-11 cells.
DIX-01 mediates protein degradation through the proteasomal pathway.
DIX-01 does not degrade CK1α.
DIX-01 exhibits potent cytotoxicity in multiple cancer cell lines (22Rv1, MV4-11, HL-60, MOLM13), with IC50 values in the nanomolar range.
DIX-01 significantly inhibits tumor growth in a zebrafish xenograft model transplanted with human acute myeloid leukemia cells (MV4-11).

物理化学性质&存储条件

分子量	538.60
分子式	C31H30N4O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2,6-dioxopiperidin-3-yl)-4-((2-((4-ethyl-5-methyl-5,6-dihydrophenanthridin-9-yl)oxy)ethyl)amino)isoindoline-1,3-dione

参考文献

1. Tang C, et al. Bioorg Chem. 2026 Feb;169:109367.

DIX-01 (DIX01)

生物&药学活性

物理化学性质&存储条件

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DIX-01 (DIX01)

生物&药学活性

物理化学性质&存储条件

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