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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-RAD51-DIDS
DIDS

Chemical Structure : DIDS

CAS No.: 304655-84-3

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DIDS

货号: PC-61230Not For Human Use, Lab Use Only.

DIDS is a small molecule inhibitor of RAD51-mediated homologous recombination.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

DIDS is a small molecule inhibitor of RAD51-mediated homologous recombination.
DIDS inhibits repair of activation-induced cytidine deaminase (AID)-initiated DNA breaks, induces apoptosis, and promotes cytotoxicity preferentially in AID-expressing human CLL;.
DIDS strongly inhibits T1D development in NOD mice.

物理化学性质&存储条件

分子量 516.483
分子式 C16H10N2Na2O7S4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4,4'-diisothiocyanatostilbene-2, 2'-disulfonic acid disodium hydrate

参考文献

1. Ratiu JJ, et al. J Immunol. 2017 Jun 1;198(11):4255-4267.

2. Lamont KR, et al. Exp Med. 2013 May 6;210(5):1021-33.

3. Dinnen RD, et al. Mol Cancer Ther. 2013 Dec;12(12):2792-803.

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