DHP-103 | KCa3.1 inhibitor | Probechem Biochemicals

Chemical Structure : DHP-103

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DHP-103 (DHP103)

货号: PC-24526Not For Human Use, Lab Use Only.

DHP-103 is a potent, highly selective inhibitor of intermediate-conductance calcium-activated K+ channel KCa3.1 with IC50 of 6.1 nM, exhibits exquisite selectivity over calcium channels and a panel of >100 additional molecular targets.

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生物&药学活性

DHP-103 is a potent, highly selective inhibitor of intermediate-conductance calcium-activated K+ channel KCa3.1 with IC50 of 6.1 nM, exhibits exquisite selectivity over calcium channels and a panel of >100 additional molecular targets.
DHP-103 binds to the water-filled central cavity of the KCa3.1 channel pore,directly impedes ion permeation.
DHP-103 inhibits gain-of-function mutant KCa3.1 channels that cause hereditary xerocytosis.
DHP-103 administered 12 h postischemic insult in proof-of-concept studies reduced infarct volume, improved balance beam performance (measure of proprioception) and decreased numbers of activated microglia in infarcted areas in rat model of acute ischemic stroke.

物理化学性质&存储条件

分子量	359.28
分子式	C16H13F4NO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	dimethyl 4-(4-fluoro-3-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3,5-dicarboxylate

参考文献

1. Ong ST, et al. Proc Natl Acad Sci U S A. 2025 May 6;122(18):e2425494122.

DHP-103 (DHP103)

生物&药学活性

物理化学性质&存储条件

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DHP-103 (DHP103)

生物&药学活性

物理化学性质&存储条件

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