DFL23916

Chemical Structure : DFL23916

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货号: PC-24589Not For Human Use, Lab Use Only.

DFL23916 is a new selective, dual GPR40 and GPR120 agonist with AC50 of 16.6 µM on human GPR120 short isoform and AC50 of 13.7 µM on human GPR40.

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生物&药学活性

DFL23916 is a new selective, dual GPR40 and GPR120 agonist with AC50 of 16.6 µM on human GPR120 short isoform and AC50 of 13.7 µM on human GPR40.
DFL23916 has AC50 of 10.2 ± 0.5 µM and 11.5 ± 0.8 µM towards huamn GPR120 and GPR40, respectively, in β-arrestin assays.
DFL23916 shows no activity towards several receptors as hGLP1R, hGPR43, hGPR119, hTGR5, with an AC50 > 1 mM.
DFL23916 is a dual agonist of mouse GPR120 and GPR40.
DFL23916 stimulates GLP-1 secretion in human NCI-H716 and in mouse STC-1 enteroendocrine cell lines.
DFL23916 (100 mg/kg, p.o.) significantly reduced the glycemia excursion after glucose in vivo.challenge

物理化学性质&存储条件

分子量	469.57
分子式	C26H28FNO4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-(3-(N-(6-fluoro-4-methyl-[1,1'-biphenyl]-3-yl)sulfamoyl)phenyl)heptanoic acid

参考文献

1. Bianchini G, et al. Biomed Pharmacother. 2021 Jul;139:111613.

DFL23916

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物理化学性质&存储条件

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DFL23916

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