DEPTOR-IN-2 | DEPTOR inhibitor | Probechem Biochemicals

Chemical Structure : DEPTOR-IN-2

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DEPTOR-IN-2 (Compound 3g, Drug 3g)

货号: PC-27311Not For Human Use, Lab Use Only.

规格	价格	库存	数量
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100 mg		Get quote

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生物&药学活性

DEPTOR-IN-2 (Compound 3g, Drug 3g) is a small molecule inhibitor of DEPTOR-mTOR interaction, prevents binding of recombinant DEPTOR to mTOR with IC50 of 1 uM, induces DEPTOR degradation, shows anti-myeloma cytotoxic properties.
DEPTOR-IN-2 (Compound 3g, Drug 3g) inhibits 8226 cells in MTT assays with IC50 of 0.12 uM.
DEPTOR-IN-2 (Compound 3g, Drug 3g) (0.5 uM) prevents DEPTOR-mTOR binding in MM cells.
DEPTOR-IN-2 (Compound 3g, Drug 3g) decreases phosphorylation of AKT (T308) in 8226 and OPM-2 MM cells.
DEPTOR-IN-2 (Compound 3g, Drug 3g) induces p70 phosphorylation.
DEPTOR-IN-2 (Compound 3g, Drug 3g) (5 and 10 mg/kg, daily IP injection) demonstrates slowing tumor growth and prolonging survival in xenograft tumors.

物理化学性质&存储条件

分子量	375.98
分子式	C12H5Cl4F3N2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(Perchlorocyclopenta-2,4-dien-1-ylidene)-2-(3-(trifluoromethyl)phenyl)hydrazine

参考文献

1. Jihye Lee, et al. Bioorg Med Chem Lett. 2017 Oct 15;27(20):4714-4724.

2. Vega MI, et al. Mol Cancer Ther. 2019 Oct;18(10):1822-1831.

DEPTOR-IN-2 (Compound 3g, Drug 3g)

生物&药学活性

物理化学性质&存储条件

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DEPTOR-IN-2 (Compound 3g, Drug 3g)

生物&药学活性

物理化学性质&存储条件

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