DEPTOR-IN-1 | DEPTOR inhibitor | Probechem Biochemicals

Chemical Structure : DEPTOR-IN-1

CAS No.: 2615911-12-9

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DEPTOR-IN-1 (Compound C3)

货号: PC-27309Not For Human Use, Lab Use Only.

DEPTOR-IN-1 (Compound C3) is a small molecule putative DEPTOR inhibitor with MST KD of 9.3 uM, exhibits antimultiple myeloma activity with IC50 of 1.09 uM for RPMI 8226 cells.

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5 mg	￥2180	In stock
10 mg	￥3580	In stock
25 mg	￥5580	In stock
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100 mg		Get quote

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生物&药学活性

DEPTOR-IN-1 (Compound C3) is a small molecule putative DEPTOR inhibitor with MST KD of 9.3 uM, exhibits antimultiple myeloma activity with IC50 of 1.09 uM for RPMI 8226 cells.
DEPTOR-IN-1 induces RPMI 8226 apoptosis, and blocks cell cycle in the S phase.
DEPTOR-IN-1 displays satisfactory inhibition of tumor growth in RPMI 8226 xenografts without obvious side effects.
DEPTOR is a 48kDa protein that binds to mTOR and inhibits this kinase within mTORC1 and mTORC2 complexes.
DEPTOR inhibits mTORC1 and mTORC2 to induce autophagy.

物理化学性质&存储条件

分子量	472.29
分子式	C24H16Cl2FNO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(3,4-dichlorophenyl)-9-(3-fluorobenzyl)-3-hydroxy-9,10-dihydro-4H,8H-chromeno[8,7-e][1,3]oxazin-4-one

参考文献

1. Hou Y, et al. J Med Chem. 2021 Oct 28;64(20):14942-14954.

DEPTOR-IN-1 (Compound C3)

生物&药学活性

物理化学性质&存储条件

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DEPTOR-IN-1 (Compound C3)

生物&药学活性

物理化学性质&存储条件

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