DEL-C1

Chemical Structure : DEL-C1

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货号: PC-25794Not For Human Use, Lab Use Only.

DEL-C1 is a small molecule inhibitor of Chitinase-3-like protein 1 (CHI3L1, YKL-40) with SPR Kd of 4.6 uM, restores astrocytic Aβ clearance and lysosomal function disrupted by CHI3L1, inhibits CHI3L1-induced NF-κB activation in human astrocytes.

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生物&药学活性

DEL-C1 is a small molecule inhibitor of Chitinase-3-like protein 1 (CHI3L1, YKL-40) with SPR Kd of 4.6 uM, restores astrocytic Aβ clearance and lysosomal function disrupted by CHI3L1, inhibits CHI3L1-induced NF-κB activation in human astrocytes.

物理化学性质&存储条件

分子量	695.88
分子式	C38H45N7O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(1R,2R)-N-((S)-1-(1H-indol-3-yl)-4-(((R)-3-(methylamino)-3-oxo-1-phenylpropyl)amino)-4-oxobutan-2-yl)-2-(((2-(2,4-dimethylthiazol-5-yl)oxazol-5-yl)methyl)amino)cyclohexane-1-carboxamide

参考文献

1. Kaur B, et al. bioRxiv [Preprint]. 2025 Oct 21:2025.10.20.683491.

DEL-C1

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DEL-C1

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