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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Chitinase-DEL-C1
DEL-C1

Chemical Structure : DEL-C1

CAS No.:

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DEL-C1

货号: PC-25794Not For Human Use, Lab Use Only.

DEL-C1 is a small molecule inhibitor of Chitinase-3-like protein 1 (CHI3L1, YKL-40) with SPR Kd of 4.6 uM, restores astrocytic Aβ clearance and lysosomal function disrupted by CHI3L1, inhibits CHI3L1-induced NF-κB activation in human astrocytes.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

DEL-C1 is a small molecule inhibitor of Chitinase-3-like protein 1 (CHI3L1, YKL-40) with SPR Kd of 4.6 uM, restores astrocytic Aβ clearance and lysosomal function disrupted by CHI3L1, inhibits CHI3L1-induced NF-κB activation in human astrocytes.

物理化学性质&存储条件

分子量 695.88
分子式 C38H45N7O4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(1R,2R)-N-((S)-1-(1H-indol-3-yl)-4-(((R)-3-(methylamino)-3-oxo-1-phenylpropyl)amino)-4-oxobutan-2-yl)-2-(((2-(2,4-dimethylthiazol-5-yl)oxazol-5-yl)methyl)amino)cyclohexane-1-carboxamide

参考文献

1. Kaur B, et al. bioRxiv [Preprint]. 2025 Oct 21:2025.10.20.683491.

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