欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Epigenetics-HDAC-DDI199
DDI199

Chemical Structure : DDI199

CAS No.: 3060093-85-5

加入收藏

DDI199 (Contilistat, DDI-199)

货号: PC-24425Not For Human Use, Lab Use Only.

DDI199 (Contilistat) is a novel multi-target molecule by linking Contilisant and Vorinostat (SAHA), inhibits histone deacetylases (HDACs), monoamine oxidases (MAOs) and cholinesterases (ChEs), and modulate histamine H3 (H3R) and Sigma 1 Receptor (S1R) receptors, shows anti-tumor activity against glioma stem cells (GSCs).

规格 价格 库存 数量
50 mg Get quote
100 mg Get quote
250 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

DDI199 (Contilistat) is a novel multi-target molecule by linking Contilisant and Vorinostat (SAHA), inhibits histone deacetylases (HDACs), monoamine oxidases (MAOs) and cholinesterases (ChEs), and modulate histamine H3 (H3R) and Sigma 1 Receptor (S1R) receptors, shows anti-tumor activity against glioma stem cells (GSCs).
DDI199 inhibits HDAC1 and HDAC5 with IC50 of 0.377 uM and 0.095 uM respectively.
DDI199 does not alter the levels of HDAC6 but promoted a decrease in HDAC1 in U87-MG cells, inhibits MAO-B with IC50 of 14.86 uM, also inhibits both AChE and BChE (Ki=0.87 uM).
DDI199 is cytotoxic for glioma cells and patient-derived stem cells in vitro (IC50<5 uM), also is cytotoxici to other tested tumor cells including gastric, pancreatic and lung cancer cells.
DDI199 deregulates pathways related to cell cycle and neurotransmission in GSCs.
DDI199 (15 mg/kg, i,p, 5 times per week for 4 weeks) reduces GBM , tumorigenicity in vivo, also shows a synergistic effect with TMZ chemotherapy.

物理化学性质&存储条件

分子量 636.81
分子式 C34H44N4O6S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N1-hydroxy-N8-((1-(phenylsulfonyl)-5-(3-(piperidin-1-yl)propoxy)-1H-indol-2-yl)methyl)-N8-(prop-2-yn-1-yl)octanediamide

参考文献

1. Artetxe-Zurutuza A, et al. Cell Death Dis. 2025 Apr 4;16(1):250.

2. Diez-Iriepa D T-PM, et al. ChemRxiv. 2023;Version 1.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: