DD1E5

Chemical Structure : DD1E5

加入收藏

货号: PC-27827Not For Human Use, Lab Use Only.

DD1E5 is a competitive inhibitor of dimethylarginine dimethylaminohydrolase1 (DDAH1) with Ki of 2.05 uM, inhibits cancer cell proliferation and a subsequent decrease in NO production with ADMA accumulation.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

DD1E5 is a competitive inhibitor of dimethylarginine dimethylaminohydrolase1 (DDAH1) with Ki of 2.05 uM, inhibits cancer cell proliferation and a subsequent decrease in NO production with ADMA accumulation.
DD1E5 reversed the elevated VEGF, c-Myc, HIF-1α, and iNOS levels induced by exogenous DDAH1 overexpression in PCa cells.
DD1E5 significantly increased intracellular levels of ADMA and reduced NO production.
DD1E5 abrogated the secretion of angiogenic factors (bFGF and IL-8) into conditional media.
DD1E5 inhibited in vivo growth of xenograft tumors derived from PCa cells with DDAH1 overexpression, by reducing tumor endothelial content represented with low CD31 expression.

物理化学性质&存储条件

分子量	400.44
分子式	C16H15F3N4OS2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-amino-6-tert-butyl-N-(1,3-thiazol-2-yl)-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxamide

参考文献

1. Kami Reddy KR, et al. ACS Comb Sci. 2019 Apr 8;21(4):241-256.

DD1E5

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

DD1E5

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.