DCY1020 | TMEM175 agonist | Probechem Biochemicals

Chemical Structure : DCY1020

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DCY1020 (DCY-1020)

货号: PC-25468Not For Human Use, Lab Use Only.

DCY1020 is a potent, specific small molecule agonist of transmembrane protein 175 (TMEM175) with EC50 of 3.7 uM, binds to TMEM175 with SPR KD of 8.3 uM.

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生物&药学活性

DCY1020 is a potent, specific small molecule agonist of transmembrane protein 175 (TMEM175) with EC50 of 3.7 uM, binds to TMEM175 with SPR KD of 8.3 uM.
DCY1020 activates TMEM175 more effectively than DCPIB (Cat# PC-72941).
DCY1020 greatly enhances the amplitude of Cs+ and H+ current (85.3 ± 8.9-fold for Cs+ current and 88.4 ± 4.0-fold for H+ current at 30 μM) in whole-endolysosome patch-clamp recordings.

物理化学性质&存储条件

分子量	451.39
分子式	C22H28Cl2N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(3-(1H-tetrazol-5-yl)propoxy)-2-butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1H-inden-1-one

参考文献

1. Xuewu Zhu, et al. Structural insights into the activation of TMEM175 by small molecule. Neuron. 2025 Aug 22:S0896-6273(25)00556-2.

DCY1020 (DCY-1020)

生物&药学活性

物理化学性质&存储条件

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DCY1020 (DCY-1020)

生物&药学活性

物理化学性质&存储条件

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