DCLK1 inhibitor a24

Chemical Structure : DCLK1 inhibitor a24

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货号: PC-24446Not For Human Use, Lab Use Only.

DCLK1 inhibitor a24 is an effective inhibitor of doublecortin-like kinase 1 (DCLK1) with IC50 of 179.7 nM, KD of 2.12 uM.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

DCLK1 inhibitor a24 is an effective inhibitor of doublecortin-like kinase 1 (DCLK1) with IC50 of 179.7 nM, KD of 2.12 uM.
a24 effectively inhibited lipopolysaccharide (LPS)-induced inflammation via inhibiting DCLK1-mediated IKKβ phosphorylation.
a24 exhibited stronger anti-inflammatory activity than NVP-TAE684.
a24 showed in vivo anti-inflammatory activity in an LPS-challenged acute lung injury model.

物理化学性质&存储条件

分子量	590.16
分子式	C26H32ClN7O3S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)-4-methylpiperazine-1-carbothioamide

参考文献

1. Cai B, et al. Bioorg Chem. 2024 Apr;145:107215.