DCLK1 inhibitor 12n

Chemical Structure : DCLK1 inhibitor 12n

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货号: PC-25592Not For Human Use, Lab Use Only.

DCLK1 inhibitor 12n is a potent, selective Doublecortin-like Kinase 1 (DCLK1) inhibitor with IC50 of 58 nM, exhibits notable DCLK1 inhibitory activity at the cellular level with IC50 of 25 nM.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

DCLK1 inhibitor 12n is a potent, selective Doublecortin-like Kinase 1 (DCLK1) inhibitor with IC50 of 58 nM, exhibits notable DCLK1 inhibitory activity at the cellular level with IC50 of 25 nM.
DCLK1 inhibitor 12n decreases the phosphorylation level of IKK in RAW264.7 cells, induces down-regulation and up-regulation for downstream p-IκB-α and IκB-α levels respectively.
DCLK1 inhibitor 12n shows anti-inflammatory activity test in vitro.
DCLK1 inhibitor 12n (5 mg/kg) demonstrated superior therapeutic efficacy in ALI and sepsis models.

物理化学性质&存储条件

分子量	541.66
分子式	C30H35N7O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((2-Methoxy-4-(3,9-diazaspiro[5.5]undecane-3-carbonyl)phenyl)amino)-5,11-dimethyl-5,11-dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-one

参考文献

1. Shanchao Wu, et al. J Med Chem. 2025 Oct 7. doi: 10.1021/acs.jmedchem.5c01811.