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首页-小分子抑制剂&激动剂-Others-Other Targets-DC-SX029
DC-SX029

Chemical Structure : DC-SX029

CAS No.: 300713-88-6

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DC-SX029 (DC-SX 029)

货号: PC-72765Not For Human Use, Lab Use Only.

DC-SX029 is a new small-molecule sorting nexin 10 (SNX10) inhibitor (KD=0.935 uM), blocks the SNX10-PIKfyve interaction, decreases TBK1/c-Rel signaling activation.

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5 mg ￥1380 In stock
10 mg ￥2180 In stock
25 mg ￥3780 In stock
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纯度 & COA & 质检文件 纯度: 99.5% (HPLC) Select Batch:

生物&药学活性

DC-SX029 is a new small-molecule sorting nexin 10 (SNX10) inhibitor (KD=0.935 uM), blocks the SNX10-PIKfyve interaction, decreases TBK1/c-Rel signaling activation.
DC-SX029 reduced inflammatory response by inhibiting PIKfyve-mediated TBK1/c-Rel signal activation in BMDMs, inhibited mRNA levels of proinflammatory cytokines IL12/23 with IC50 of 18.6 uM.
DC-SX029 alleviated DSS-induced mouse colitis, improved IL-10-deficient mouse colitis.

物理化学性质&存储条件

分子量 398.353
分子式 C14H17F3N2O6S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5,5,5-trifluoro-4-(((4-((methoxycarbonyl)amino)phenyl)sulfonamido)methyl)pentanoic acid

参考文献

1. Weilian Bao, et al. Pharmacol Res. 2021 Jul;169:105679.

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