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首页-小分子抑制剂&激动剂-Autophagy-DC-LC3in-D5
DC-LC3in-D5

Chemical Structure : DC-LC3in-D5

CAS No.: 2868312-73-4

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DC-LC3in-D5

货号: PC-72653Not For Human Use, Lab Use Only.

DC-LC3in-D5 is a small molecule covalent modulator of LC3A/B and autophagy inhibitor, binds to LC3B and covalently modifies Lysine 49.

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10 mg ￥3580 In stock
25 mg ￥5980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

DC-LC3in-D5 is a small molecule covalent modulator of LC3A/B and autophagy inhibitor, binds to LC3B and covalently modifies Lysine 49.
DC-LC3in-D5 selectively reacts with LC3A/B in vitro (IC50=200 nM, FP assays)
DC-LC3in-D5 exhibits a potent covalent reactivity and selectivity to LC3A/B in HeLa cells, disrupts the ATG7-LC3B interaction and blocks LC3B lipidation.
DC-LC3in-D5 compromises LC3B lipidation in vitro and in HeLa cells, leading to deficiency in the formation of autophagic structures and autophagic substrate degradation.
DC-LC3in-D5 is a powerful tool for autophagy research with little cellular toxicity.
The autophagic ubiquitin-like protein LC3 functions through interactions with LC3-interaction regions (LIRs) of other autophagy proteins, including autophagy receptors, which stands out as a promising protein–protein interaction (PPI) target for the intervention of autophagy.

物理化学性质&存储条件

分子量 397.296
分子式 C19H22Cl2N2O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-(2,3-dichlorophenyl)-2-(((2-morpholinoethyl)amino)methylene)cyclohexane-1,3-dione

参考文献

1. Shijie Fan, et al. Angew Chem Int Ed Engl. 2021 Dec 6;60(50):26105-26114.

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