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首页-小分子抑制剂&激动剂-Autophagy-Autophagy-related Protein (Atg)-DC-ATG4in
DC-ATG4in

Chemical Structure : DC-ATG4in

CAS No.: 690673-29-1

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DC-ATG4in

货号: PC-20716Not For Human Use, Lab Use Only.

DC-ATG4in is a small molecule autophagy related 4B (ATG4B) inhibitor, directly binds to ATG4B and inhibits its enzyme activity with IC50 of 3.08 uM, DC-ATG4in is an autophagy inhibitor.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    DC-ATG4in is a small molecule autophagy related 4B (ATG4B) inhibitor, directly binds to ATG4B and inhibits its enzyme activity with IC50 of 3.08 uM, DC-ATG4in is an autophagy inhibitor.
    DC-ATG4in blocked autophagy induced by Sorafenib in Hepatocellular Carcinoma (HCC) cells.
    Combination of DC-ATG4in with Sorafenib synergized the cancer cell killing effect and proliferation inhibition activities on HCC cells.

    物理化学性质&存储条件

    分子量 418.52
    分子式 C23H22N4O2S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(2,3-di(furan-2-yl)quinoxalin-6-yl)azepane-1-carbothioamide

    参考文献

    1. Yanqiu Xie, et al. Bioorg Med Chem. 2023 Apr 15;84:117262.

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