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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-p97/VCP-DBeQ
DBeQ

Chemical Structure : DBeQ

CAS No.: 177355-84-9

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DBeQ (JRF 12)

货号: PC-24319Not For Human Use, Lab Use Only.

DBeQ is a selective, potent, reversible, and ATP-competitive AAA ATPase p97/VCP inhibitor with IC50 of 1.5 μM and 1.6 μM for p97(wt) and p97(C522A) respectively, also inhibits VPS4 with IC50 of 11.5 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

DBeQ is a selective, potent, reversible, and ATP-competitive AAA ATPase p97/VCP inhibitor with IC50 of 1.5 μM and 1.6 μM for p97(wt) and p97(C522A) respectively, also inhibits VPS4 with IC50 of 11.5 uM.
DBeQ blocks multiple processes that have been shown by RNAi to depend on p97, including degradation of ubiquitin fusion degradation and endoplasmic reticulum-associated degradation pathway reporters, as well as autophagosome maturation.
DBeQ also potently inhibits cancer cell growth at mobilizing the executioner caspases-3 and -7.
DBeQ enhances sorafenib-mediated toxicity in cultured hepatocellular carcinoma (HCC) cells.

物理化学性质&存储条件

分子量 340.43
分子式 C22H20N4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N2,N4-Dibenzylquinazoline-2,4-diamine

参考文献

1. Chou TF, et al. Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):4834-9.

2. Yi P, et al. Mol Cancer Ther. 2012 Dec;11(12):2610-20.

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