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首页-小分子抑制剂&激动剂-Others-Other Targets-DB2313
DB2313

Chemical Structure : DB2313

CAS No.: 2170606-74-1

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DB2313 (DB 2313)

货号: PC-62744Not For Human Use, Lab Use Only.

DB2313 is a small-molecule transcription factor PU.1 inhibitor abrogating DNA binding by PU.1 with Kd of 29 nM.

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5 mg ￥1380 In stock
10 mg ￥2180 In stock
25 mg ￥3780 In stock
50 mg ￥5880 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

DB2313 is a small-molecule transcription factor PU.1 inhibitor abrogating DNA binding by PU.1 with Kd of 29 nM.
DB2313 decrease cell growth (IC50=7.1 uM) and the clonogenic capacity of AML cells and leads to increased apoptosis, while showing little effect on normal hematopoietic cells.
DB2313 decreases tumor burden and increases survival in murine and human AML transplantation models.

物理化学性质&存储条件

分子量 708.842
分子式 C42H41FN8O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2,2'-((((2-fluoro-1,3-phenylene)bis(methylene))bis(oxy))bis(4,1-phenylene))bis(N-isopropyl-1H-benzo[d]imidazole-6-carboximidamide)

参考文献

1. Antony-Debré I, et al. J Clin Invest. 2017 Oct 30. pii: 92504.

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