DB-0646 | Multi-target PROTAC | Probechem Biochemicals

Chemical Structure : DB-0646

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DB-0646 (DB0646)

货号: PC-27685Not For Human Use, Lab Use Only.

DB-0646 is a multi-target PROTAC degrader that degrades over a panel of 125 distinct kinases in various cell lines, induces ubiquitination and degradation of GCK, BUB1 and YES1.

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生物&药学活性

DB-0646 is a multi-target PROTAC degrader that degrades over a panel of 125 distinct kinases in various cell lines, induces ubiquitination and degradation of GCK, BUB1 and YES1.

物理化学性质&存储条件

分子量	1041.07
分子式	C52H51F3N14O7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzamide, N-[3-[7-[[6-[4-[[1-[5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]pentyl]-1H-1,2,3-triazol-4-yl]methyl]-1-piperazinyl]-3-pyridinyl]amino]-1,4-dihydro-1-methyl-2-oxopyrimido[4,5-d]pyrimidin-3(2H)-yl]-4-methylphenyl]-3-(trifluoromethyl)-

参考文献

1. Donovan KA, et al. Cell. 2020 Dec 10;183(6):1714-1731.e10.

DB-0646 (DB0646)

生物&药学活性

物理化学性质&存储条件

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DB-0646 (DB0646)

生物&药学活性

物理化学性质&存储条件

参考文献

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