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首页-小分子抑制剂&激动剂-PI3K/Akt/mTOR Pathway-PI3K-D223
D223

Chemical Structure : D223

CAS No.: 2253733-45-6

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D223 (DS02312223)

货号: PC-25225Not For Human Use, Lab Use Only.

D927 (DS11252927) is a small molecule glue and GLUT4 activator that facilitate RAS binding to PI3Kα, promotes glucose uptake in the absence of insulin, binds directly to p110α with dissociation constant (KD) of 0.76 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

D927 (DS11252927) is a small molecule glue and GLUT4 activator that facilitate RAS binding to PI3Kα, promotes glucose uptake in the absence of insulin, binds directly to p110α with dissociation constant (KD) of 0.76 uM.

物理化学性质&存储条件

分子量 581.66
分子式 C29H32FN5O5S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

tert-butyl (2-(2-(2-(4-((4-(2-amino-2-oxoethyl)-2-fluorophenyl)amino)thieno[2,3-d]pyridazin-7-yl)phenoxy)ethoxy)ethyl)carbamate

参考文献

1. Terayama K, et al. Science. 2025 Jul 24;389(6758):402-408.

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