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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-YAP-TEAD-Cyclovirobuxine D
Cyclovirobuxine D

Chemical Structure : Cyclovirobuxine D

CAS No.: 860-79-7

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Cyclovirobuxine D (CVB-D)

货号: PC-24744Not For Human Use, Lab Use Only.

Cyclovirobuxine D (CVB-D) is a naturally alkaloid, induces autophagy and attenuates the phosphorylation of Akt and mTOR, exerts its anti-cancer effects by directly binding to YAP, inhibits the nuclear translocation of YAP/TAZ and suppresses the transcription of downstream oncogenic target genes.

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10 mg ￥580 In stock
25 mg ￥980 In stock
50 mg ￥1580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Cyclovirobuxine D (CVB-D) is a naturally alkaloid, induces autophagy and attenuates the phosphorylation of Akt and mTOR, exerts its anti-cancer effects by directly binding to YAP, inhibits the nuclear translocation of YAP/TAZ and suppresses the transcription of downstream oncogenic target genes.
Cyclovirobuxine D (CVB-D) could improve cardiac dysfunction in a cecal ligation and puncture (CLP) model in rodents and in a lipopolysaccharide (LPS) model in vitro.
Cyclovirobuxine D ameliorates acute myocardial ischemia by K(ATP) channel opening, nitric oxide release and anti-thrombosis. also is an inhibitor of cytoplasmic leukemia inhibitory factor (LIF) in HCC, suppresses proliferation and metastasis by activating p38MAPK/p62-modulated mitophagy.
Cyclovirobuxine D inhibits triple-negative breast cancer via YAP/TAZ suppression and activation of the FOXO3a/PINK1-Parkin pathway-induced mitophagy.
Cyclovirobuxine D triggers autophagy to suppress the proliferation of TNBC and promote TNBC apoptosis.
Cyclovirobuxine D exhibits notable antitumor activity against diverse tumor types.

物理化学性质&存储条件

分子量 402.67
分子式 C26H46N2O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(2aR,3S,4R,5aS,5bS,7aR,9S,11aR,12aS)-2a,5a,8,8-Tetramethyl-9-(methylamino)-3-((S)-1-(methylamino)ethyl)tetradecahydro-1H,12H-cyclopenta[a]cyclopropa[e]phenanthren-4-ol

参考文献

1. Gao K, et al. Naunyn Schmiedebergs Arch Pharmacol. 2025 Jan 11.

2. Wang ZQ, et al. Phytomedicine. 2025 Jan;136:156287.

3. Hu D, et al. Eur J Pharmacol. 2007 Aug 13;569(1-2):103-9.

4. Lu J, et al. J Pharmacol Sci. 2014;125(1):74-82.

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