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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Cyclin-dependent Kinase (CDK)-Cyclin K MGD S656
Cyclin K MGD S656

Chemical Structure : Cyclin K MGD S656

CAS No.:

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Cyclin K MGD S656

货号: PC-27702Not For Human Use, Lab Use Only.

Cyclin K MGD S656 is a molecular glue degrader (MGD) that mediates the CRL4-dependent proteolysis of cyclin K with IC50 of 743 nM in OCI-AML5 cells, mediates cyclin K degradation through the cullin RING ubiquitin ligase complex.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

Cyclin K MGD S656 is a molecular glue degrader (MGD) that mediates the CRL4-dependent proteolysis of cyclin K with IC50 of 743 nM in OCI-AML5 cells, mediates cyclin K degradation through the cullin RING ubiquitin ligase complex.
S656 suppresses expression of DDR genes and induces DNA lesions in OCI-AML5 cells.
S656 inhibits the kinase activity of CDK12-cyclin K in vitro (IC50=6.0 uM).
S656 efficiently induces an interaction between CDK12 and DDB1.

物理化学性质&存储条件

分子量 384.52
分子式 C19H20N4OS2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(4-(dimethylamino)phenyl)-N-(5-((pyridin-3-ylmethyl)thio)thiazol-2-yl)acetamide

参考文献

1. Moison C, et al. EMBO Rep. 2025 Jun;26(11):2836-2854.

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