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首页-小分子抑制剂&激动剂-Epigenetics-Histone Acetyltransferase (HAT)-Curcumin
Curcumin

Chemical Structure : Curcumin

CAS No.:

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Curcumin (Diferuloylmethane, Natural Yellow 3)

货号: PC-24370Not For Human Use, Lab Use Only.

Curcumin (Diferuloylmethane) is a specific p300/CREB-binding protein acetyltransferase, inhibits acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Curcumin (Diferuloylmethane) is a specific p300/CREB-binding protein acetyltransferase, inhibits acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription.
Curcumin shows inhibitory effects on NF-κB and MAPKs, and has diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities.
Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification.

物理化学性质&存储条件

分子量 368.39
分子式 C21H20O6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione

参考文献

1. Zhu X, et al. PLoS One. 2014 Mar 6;9(3):e91303.

2. Balasubramanyam K, et al. J Biol Chem. 2004 Dec 3;279(49):51163-71.

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