CuATSM

Chemical Structure : CuATSM

CAS No.: 68341-09-3

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货号: PC-24567Not For Human Use, Lab Use Only.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg	￥2980	In stock
100 mg		Get quote

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生物&药学活性

CuATSM is orally available brain-penetrant copper compound that scavenges free radicals, inhibits lipid peroxidation and ferroptosis, stabilises various ALS-associated variants of the SOD1 protein, reducing misfolding and toxicity.
CuATSM potently inhibits ferroptosis, prevented SMC phenotypic switch, neointimal formation and arterial inflammation in mice.
CuATSM protects against a broad variety of SOD1 mutations in cell culture model of SOD1-fALS
CuATSM improves motor function and extends survival but is not tolerated at a high dose in SOD1G93A mice with a C57BL/6 background
CuATSM has repeatedly shown in mouse models to be a promising therapeutic treatment for SOD1-associated ALS and is currently in Phase II/III clinical trials for the treatment of ALS.

物理化学性质&存储条件

分子量	321.91
分子式	C8H14CuN6S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Diacetylbis(N(4)-methylthiosemicarbazonato)copper(II)

参考文献

1. Lum JS, et al. EBioMedicine. 2025 Apr 12;115:105692.

2. Farrawell NE, et al. ACS Chem Neurosci. 2019 Mar 20;10(3):1555-1564.

3. Ji QX, et al. Cell Death Differ. 2023 Feb;30(2):457-474.

4. Lum JS, et al. Sci Rep. 2021 Sep 29;11(1):19392.

CuATSM

生物&药学活性

物理化学性质&存储条件

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CuATSM

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