Concanamycin A (Folimycin) | V-ATPase inhibitor | Probechem Biochemicals

Chemical Structure : Concanamycin A

CAS No.: 80890-47-7

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Concanamycin A (Folimycin, Antibiotic X 4357B)

货号: PC-27521Not For Human Use, Lab Use Only.

Concanamycin A (Folimycin) is a potent, specific inhibitor of vacuolar type H+-ATPase (V-ATPase) with IC50 of 9.2 nM, does not inhibit F-type and P-type H+-ATPases.

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25 ug	￥1780	In stock
50 ug	￥2880	In stock
100 ug	￥4880	In stock
500 ug		Get quote

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生物&药学活性

Concanamycin A (Folimycin) is a potent, specific inhibitor of vacuolar type H+-ATPase (V-ATPase) with IC50 of 9.2 nM, does not inhibit F-type and P-type H+-ATPases.
Concanamycin A inhibits intracellular translocation of envelope glycoprotein of VSV.
Concanamycin A blocks intracellular translocation of glycoprotein at the latest before reaching the trans Golgi network where the processing of N-glycans is completed.
Concanamycin A induces cell death in activated CD8(+) CTL.
Concanamycin A is also an inhibitor of lysosomal acidification.

物理化学性质&存储条件

分子量	866.10
分子式	C46H75NO14
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2R,3S,4R,6R)-6-(((2R,4R,5S,6R)-2-((2S,3R,4S)-4-((2R,3S,4E,6Z,9R,10S,11S,12R,13R,14E,16Z)-11-ethyl-10,12-dihydroxy-3,17-dimethoxy-7,9,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6,14,16-tetraen-2-yl)-3-hydroxypentan-2-yl)-2-hydroxy-5-methyl-6-((E)-prop-1-en-1-yl)tetrahydro-2H-pyran-4-yl)oxy)-4-hydroxy-2-methyltetrahydro-2H-pyran-3-yl carbamate

参考文献

1. Muroi M, et al. Cell Struct Funct. 1993 Jun;18(3):139-49.

2. Akifusa S, et al. Exp Cell Res. 1998 Jan 10;238(1):82-9.

3. Manabe T, et al. J Cell Physiol. 1993 Dec;157(3):445-52.

4. Togashi K, et al. Cytotechnology. 1997 Nov;25(1-3):127-35.

Concanamycin A (Folimycin, Antibiotic X 4357B)

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物理化学性质&存储条件

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Concanamycin A (Folimycin, Antibiotic X 4357B)

生物&药学活性

物理化学性质&存储条件

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