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首页-小分子抑制剂&激动剂-GPCR-Dopamine Receptor-Compound 621433144
Compound 621433144

Chemical Structure : Compound 621433144

CAS No.: 2223169-38-6

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Compound 621433144 (ZINC000621433144, Z3269026405)

货号: PC-36061Not For Human Use, Lab Use Only.

Compound 621433144 (ZINC000621433144, Z3269026405) is a potent, selective full agonist of the D4 receptor with 2,500-fold subtype selectivity.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    Compound 621433144 (ZINC000621433144, Z3269026405) is a potent, selective full agonist of dopamine D4 receptor (DRD4) with 2,500-fold subtype selectivity.
    Compound 621433144 was also functionally selective, with a 17-fold bias towards Gi signalling versus β-arrestin recruitment, compared to the characteristic agonist quinpirole.

    物理化学性质&存储条件

    分子量 301.434
    分子式 C18H27N3O
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-N-((3R,4S)-1-isopropyl-4-methylpyrrolidin-3-yl)-1-methylisoindoline-2-carboxamide

    参考文献

    1. Lyu J, et al. Nature. 2019 Feb 6. doi: 10.1038/s41586-019-0917-9.

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