Compound 5-6 | FtsW inhibitor | Probechem Biochemicals

Chemical Structure : Compound 5-6

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Compound 5-6 (FtsW inhibitor 5-6)

货号: PC-21120Not For Human Use, Lab Use Only.

Compound 5-6 (FtsW inhibitor 5-6) is a specific small molecule inhibitor of bacterial cell wall polymerase FtsW, competes with Lipid II for binding to FtsW with Ki of 0.8 uM, has an MIC of 1 μg /mL against S. aureus.

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生物&药学活性

Compound 5-6 (FtsW inhibitor 5-6) is a specific small molecule inhibitor of bacterial cell wall polymerase FtsW, competes with Lipid II for binding to FtsW with Ki of 0.8 uM, has an MIC of 1 μg /mL against S. aureus.
FtsW inhibitor 5-6 is selective for inhibition of FtsWI over two other S. aureus enzymes that belong to the other class of peptidoglycan polymerases.
FtsW inhibitor 5-6 competes with Lipid II for binding to S. aureus FtsWI with Ki of 0.8 uM in competitive binding assay.
FtsW inhibitor 5-6 prevents Lipid II from binding to the donor site of FtsW.

物理化学性质&存储条件

分子量	415.45
分子式	C23H21N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2-hydroxy-5-methoxyphenyl)(2-((4,6,7-trimethylquinazolin-2-yl)amino)pyrimidin-5-yl)methanone

参考文献

1. Youngseon Park, et al. Angew Chem Int Ed Engl. 2023 Jun 19;62(25):e202301522.

Compound 5-6 (FtsW inhibitor 5-6)

生物&药学活性

物理化学性质&存储条件

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Compound 5-6 (FtsW inhibitor 5-6)

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物理化学性质&存储条件

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